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Ukhatskaya, E.V., Kurkov, S.V., Matthews, S.E. 
ORCID: https://orcid.org/0000-0001-8821-0851 and Loftsson, T.
(2013)
Encapsulation of drug molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in biopharmaceutical field.
Journal of Pharmaceutical Sciences, 102 (10).
pp. 3485-3512.
ISSN 0022-3549
Abstract
Calix[n]arenes (CAs) are supramolecular compounds able to form guest-host inclusion complexes with metal ions, small organic molecules, and small moieties of larger molecules. Although the CA literature is extensive, relatively few publications deal with water-soluble CAs, especially those containing nitrogen-based functionality. These CAs possess antibacterial and antifungal activity. Because of their molecular structure, they are surface active and also able to form water-soluble drug complexes, giving additional potential as enabling pharmaceutical excipients. This article provides an overview of the published data regarding synthesis, physicochemical properties, and pharmaceutical application of water-soluble CAs with emphasis on those that contain nitrogen-based substituents in their structure, particularly aminoCAs. In particular, it describes state-of-the-art in complexation of water-soluble CAs with pharmaceutically relevant ions and organic molecules up to amino acids, DNA, and proteins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antiinfectives,calixarene,complexation,excipients,inclusion compounds,interaction,nanoparticles,structure-activity relationship,surfactants |
| Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Science > School of Natural Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 12 May 2014 16:12 |
| Last Modified: | 03 May 2024 00:25 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/48411 |
| DOI: | 10.1002/jps.23681 |
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