EXPLOITING NANOSCALE MATERIALS PROPERTIES FOR CONTROLLED DRUG DELIVERY SYSTEMS

Che Rose, Laili (2013) EXPLOITING NANOSCALE MATERIALS PROPERTIES FOR CONTROLLED DRUG DELIVERY SYSTEMS. Doctoral thesis, University of East Anglia.

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Abstract

Abstract
The main objective of this work was to develop a novel drug delivery system
exploiting special opportunities afforded by synthesis of nanoscale materials to be
applied inside the colon. It must be robust enough to cope with the adverse
conditions in the gastrointestinal tract (GI) and be able to reach and release “on
demand” at the colon area at the right time. In this work, an oral capsule formulation
with iron oxide nanoparticles (IONs) containing coating was used to transport drug
and release drug in the colon.
With that in mind, the synthesis of poly (alkylcyanoacrylate) nanocapsules by
microemulsion polymerisation and magnetic iron oxide nanoparticles (IONs) via a coprecipitation
method were conducted. The key physical properties of the materials
were characterized employing standard techniques such as HPLC, FTIR, DSC, DLS,
XRD, TEM and SEM. Hard capsules filled with model drug, paracetamol, were
coated with IONs containing coatings (fatty acids and paraffin). The optimum
composition for the formulation of the coating embedded with the nanoparticles was
explored with respect to protection of the drug payload from conditions in the GI tract
as well as for effective release “on demand” using radio-frequency hyperthermia. The
optimum radiofrequency and the power level for heating the nanoparticles were also
determined and melting the coating using magnetic nanoparticle hyperthermia.
Results showed that paraffin-based coatings had appropriate properties for this
application. Finally, taking into account all the results, a design of a novel drug
delivery system, together with an experimental setup for testing the “release in
demand” was proposed. The approach is generic, easy to set up and could also be
applied to many other situations where delivery on demand is required.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Mia Reeves
Date Deposited: 06 Mar 2014 11:17
Last Modified: 06 Mar 2014 11:17
URI: https://ueaeprints.uea.ac.uk/id/eprint/47950
DOI:

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