Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

Lichtenstein, Laeticia, Berbée, Jimmy F P, van Dijk, Susan J, van Dijk, Ko Willems, Bensadoun, André, Kema, Ido P, Voshol, Peter J, Müller, Michael, Rensen, Patrick C N and Kersten, Sander (2007) Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arteriosclerosis, Thrombosis, and Vascular Biology, 27 (11). pp. 2420-2427. ISSN 1079-5642

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Abstract

Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein metabolism. Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4.

Item Type: Article
Uncontrolled Keywords: angiopoietins,animals,biosynthetic pathways,blood glucose,blood proteins,cholesterol,fasting,fatty acids,insulin resistance,lipolysis,lipoprotein lipase,liver,mice,mice, transgenic,triglycerides
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 11:50
Last Modified: 21 Apr 2020 22:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/47725
DOI: 10.1161/ATVBAHA.107.151894

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