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Bouwens, Mark, Afman, Lydia A and Müller, Michael 
ORCID: https://orcid.org/0000-0002-5930-9905
(2008)
Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response.
BMC Genomics, 9.
ISSN 1471-2164
Abstract
Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person. Recently, we showed that the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) has a functional role in human PBMCs during fasting. However, the extent of the role of PPARalpha in human PBMCs remains unclear. In this study, we therefore performed gene expression profiling of PBMCs incubated with the specific PPARalpha ligand WY14,643.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | amino acids,fasting,fatty acids,gene expression profiling,gene expression regulation,genome, human,humans,hypolipidemic agents,leukocytes, mononuclear,oligonucleotide array sequence analysis,ppar alpha,pyrimidines,response elements |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 21 Feb 2014 11:32 |
| Last Modified: | 06 Jun 2024 14:47 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/47707 |
| DOI: | 10.1186/1471-2164-9-262 |
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