Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids

Kersten, Sander, Lichtenstein, Laeticia, Steenbergen, Emma, Mudde, Karin, Hendriks, Henk F J, Hesselink, Matthijs K, Schrauwen, Patrick and Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905 (2009) Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arteriosclerosis, Thrombosis, and Vascular Biology, 29 (6). pp. 969-974. ISSN 1079-5642

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Abstract

Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human. Here we set out to identify physiological determinants of plasma ANGPTL4 levels in humans, focusing on the effect of energy restriction and plasma FFAs.

Item Type: Article
Uncontrolled Keywords: adrenergic beta-agonists,adult,albuterol,angiopoietins,animals,caloric restriction,cells, cultured,enzyme-linked immunosorbent assay,exercise,fat emulsions, intravenous,fatty acids, nonesterified,humans,hypolipidemic agents,intestines,liver neoplasms,male,mice,middle aged,myocytes, cardiac,rna, messenger,rats,time factors,transfection,up-regulation,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 11:56
Last Modified: 06 Jun 2024 14:47
URI: https://ueaeprints.uea.ac.uk/id/eprint/47705
DOI: 10.1161/ATVBAHA.108.182147

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