Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

de Wit, Nicole J W, Bosch-Vermeulen, Hanneke, Oosterink, Els, Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905 and van der Meer, Roelof (2011) Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice. British Journal of Nutrition, 105 (7). pp. 1005-1011. ISSN 0007-1145

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Abstract

There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2·3-fold; P

Item Type:	Article
Uncontrolled Keywords:	adipose tissue,animals,bile acids and salts,calcium, dietary,dietary fats,dietary supplements,fatty acids,feces,gene expression,insulin resistance,intestinal absorption,intestine, small,lipogenesis,lipolysis,male,mice,mice, inbred c57bl,obesity,trace elements,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	10 Jun 2014 20:42
Last Modified:	06 Jun 2024 14:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47676
DOI:	10.1017/S0007114510004654

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