Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

Meissner, Maxi, Herrema, Hilde, van Dijk, Theo H, Gerding, Albert, Havinga, Rick, Boer, Theo, Müller, Michael, Reijngoud, Dirk-Jan, Groen, Albert K and Kuipers, Folkert (2011) Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. PLoS One, 6 (11). ISSN 1932-6203

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Abstract

Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.

Item Type: Article
Uncontrolled Keywords: animals,bile acids and salts,blood glucose,carbon isotopes,carnitine,diabetes mellitus, experimental,glucose,liver,metabolic clearance rate,mice,mice, knockout,muscle, skeletal
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 11:52
Last Modified: 21 Apr 2020 22:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/47655
DOI: 10.1371/journal.pone.0024564

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