Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate
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Meissner, Maxi, Herrema, Hilde, van Dijk, Theo H, Gerding, Albert, Havinga, Rick, Boer, Theo, Müller, Michael, Reijngoud, Dirk-Jan, Groen, Albert K and Kuipers, Folkert (2011) Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. PLoS One, 6 (11). ISSN 1932-6203
Full text not available from this repository. (Request a copy)Abstract
Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.
Item Type: | Article |
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Uncontrolled Keywords: | animals,bile acids and salts,blood glucose,carbon isotopes,carnitine,diabetes mellitus, experimental,glucose,liver,metabolic clearance rate,mice,mice, knockout,muscle, skeletal |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Depositing User: | Pure Connector |
Date Deposited: | 21 Feb 2014 11:52 |
Last Modified: | 14 Sep 2020 07:03 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/47655 |
DOI: | 10.1371/journal.pone.0024564 |
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