Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

Meissner, Maxi, Herrema, Hilde, van Dijk, Theo H., Gerding, Albert, Havinga, Rick, Boer, Theo, Müller, Michael, Reijngoud, Dirk-Jan, Groen, Albert K. and Kuipers, Folkert (2011) Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. PLoS One, 6 (11). ISSN 1932-6203

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Abstract

Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.

Item Type:	Article
Uncontrolled Keywords:	animals,bile acids and salts,blood glucose,carbon isotopes,carnitine,diabetes mellitus, experimental,glucose,liver,metabolic clearance rate,mice,mice, knockout,muscle, skeletal,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	21 Feb 2014 11:52
Last Modified:	15 Oct 2025 02:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47655
DOI:	10.1371/journal.pone.0024564

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