Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone

Baumgartner, Jeannine, Smuts, Cornelius M, Malan, Linda, Arnold, Myrtha, Yee, Benjamin K, Bianco, Laura E, Boekschoten, Mark V, Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Langhans, Wolfgang, Hurrell, Richard F and Zimmermann, Michael B (2012) Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone. Journal of Nutrition, 142 (8). pp. 1463-1471. ISSN 0022-3166

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Abstract

Deficiencies of iron (Fe) (ID) and (n-3) fatty acids (FA) [(n-3)FAD] may impair brain development and function through shared mechanisms. However, little is known about the potential interactions between these 2 common deficiencies. We studied the effects of ID and (n-3)FAD, alone and in combination, on brain monoamine pathways (by measuring monoamines and related gene expression) and spatial working and reference memory (by Morris water maze testing). Using a 2 × 2 design, male rats were fed an ID, (n-3)FAD, ID+(n-3)FAD, or control diet for 5 wk postweaning (postnatal d 21-56) after (n-3)FAD had been induced over 2 generations. The (n-3)FAD and ID diets decreased brain (n-3) FA by 70-76% and Fe by 20-32%, respectively. ID and (n-3)FAD significantly increased dopamine (DA) concentrations in the olfactory bulb (OB) and striatum, with an additive 1- to 2-fold increase in ID+(n-3)FAD rats compared with controls (P

Item Type:	Article
Uncontrolled Keywords:	animal feed,animal nutritional physiological phenomena,animals,biogenic monoamines,brain,diet,fatty acids, omega-3,female,gene expression regulation,iron,male,maze learning,memory disorders,phospholipids,protein array analysis,random allocation,rats
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Pure Connector
Date Deposited:	21 Feb 2014 12:00
Last Modified:	24 Oct 2022 06:05
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47654
DOI:	10.3945/jn.111.156281

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