In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency

Baumgartner, Jeannine, Smuts, Cornelius M, Malan, Linda, Arnold, Myrtha, Yee, Benjamin K, Bianco, Laura E, Boekschoten, Mark V, Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Langhans, Wolfgang, Hurrell, Richard F and Zimmermann, Michael B (2012) In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency. Journal of Nutrition, 142 (8). pp. 1472-1478. ISSN 0022-3166

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Abstract

Concurrent deficiencies of iron (Fe) (ID) and (n-3) fatty acids [(n-3)FAD)] in rats can alter brain monoamine pathways and impair learning and memory. We examined whether repletion with Fe and DHA/EPA, alone and in combination, corrects the deficits in brain monoamine activity (by measuring monoamines and related gene expression) and spatial working and reference memory [by Morris water maze (MWM) testing] associated with deficiency. Using a 2 × 2 design, male rats with concurrent ID and (n-3)FAD [ID+(n-3)FAD] were fed an Fe+DHA/EPA, Fe+(n-3)FAD, ID+DHA/EPA, or ID+(n-3)FAD diet for 5 wk [postnatal d 56-91]. Biochemical measures and MWM performance after repletion were compared to age-matched control rats. The provision of Fe in combination with DHA/EPA synergistically increased Fe concentrations in the olfactory bulb (OB) (Fe x DHA/EPA interaction). Similarly, provision of DHA/EPA in combination with Fe resulted in higher brain DHA concentrations than provision of DHA alone in the frontal cortex (FC) and OB (P

Item Type:	Article
Uncontrolled Keywords:	animal feed,animal nutritional physiological phenomena,animals,biogenic monoamines,brain,diet,dietary supplements,fatty acids, omega-3,female,gene expression regulation,iron,male,maze learning,memory disorders,phospholipids,protein array analysis,random allocation,rats
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	10 Jun 2014 20:32
Last Modified:	06 Jun 2024 14:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47653
DOI:	10.3945/jn.111.156299

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