ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype

Minihane, Anne M. ORCID: https://orcid.org/0000-0001-9042-4226, Khan, Syrah, Leigh-Firbank, Elizabeth C., Talmud, Philippa, Wright, John W., Murphy, Margaret C., Griffin, Bruce A. and Williams, Christine M. (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology, 20 (8). pp. 1990-1997. ISSN 1079-5642

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Abstract

The study assessed the efficacy of fish oil supplementation in counteracting the classic dyslipidemia of the atherogenic lipoprotein phenotype (ALP). In addition, the impact of the common apolipoprotein E (apoE) polymorphism on the fasting and postprandial lipid profile and on responsiveness to the dietary intervention was established. Fifty-five ALP males (aged 34 to 69 years, body mass index 22 to 35 kg/m(2), triglyceride [TG] levels 1.5 to 4.0 mmol/L, high density lipoprotein cholesterol [HDL-C] 40% total LDL) completed a randomized placebo-controlled crossover trial of fish oil (3.0 g eicosapentaenoic acid/docosahexaenoic acid per day) and placebo (olive oil) capsules with the 6-week treatment arms separated by a 12-week washout period. In addition to fasting blood samples, at the end of each intervention arm, a postprandial assessment of lipid metabolism was carried out. Fish oil supplementation resulted in a reduction in fasting TG level of 35% (P

Item Type:	Article
Uncontrolled Keywords:	adult,aged,apolipoproteins e,arteriosclerosis,cholesterol, hdl,cholesterol, ldl,cross-over studies,double-blind method,fasting,fatty acids, nonesterified,fish oils,food,genotype,humans,lipoproteins,male,middle aged,phenotype,placebos,polymorphism, genetic,triglycerides
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 15:00
Last Modified:	19 Oct 2023 01:16
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47347
DOI:	10.1161/01.ATV.20.8.1990

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