Novel genetic variants associated with lumbar disc degeneration in northern Europeans:a meta-analysis of 4600 subjects

Williams, Frances M K, Bansal, Aruna T, van Meurs, Joyce B, Bell, Jordana T, Meulenbelt, Ingrid, Suri, Pradeep, Rivadeneira, Fernando, Sambrook, Philip N, Hofman, Albert, Bierma-Zeinstra, Sita, Menni, Cristina, Kloppenburg, Margreet, Slagboom, P Eline, Hunter, David J, MacGregor, Alex J, Uitterlinden, Andre G, Spector, Tim D and Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325 (2013) Novel genetic variants associated with lumbar disc degeneration in northern Europeans:a meta-analysis of 4600 subjects. Annals of the Rheumatic Diseases, 72 (7). pp. 1141-8. ISSN 0003-4967

Full text not available from this repository. (Request a copy)

Abstract

Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.

Item Type: Article
Uncontrolled Keywords: adult,aged,cpg islands,dna methylation,european continental ancestry group,female,genetic predisposition to disease,genome-wide association study,humans,intervertebral disc degeneration,lumbar vertebrae,male,middle aged,polymorphism, single nucleotide,ubiquitin-protein ligases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User: Pure Connector
Date Deposited: 27 Jan 2014 13:54
Last Modified: 19 Apr 2023 00:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/47220
DOI: 10.1136/annrheumdis-2012-201551

Actions (login required)

View Item View Item