Williams, Frances M K, Bansal, Aruna T, van Meurs, Joyce B, Bell, Jordana T, Meulenbelt, Ingrid, Suri, Pradeep, Rivadeneira, Fernando, Sambrook, Philip N, Hofman, Albert, Bierma-Zeinstra, Sita, Menni, Cristina, Kloppenburg, Margreet, Slagboom, P Eline, Hunter, David J, MacGregor, Alex J, Uitterlinden, Andre G, Spector, Tim D and Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325
(2013)
Novel genetic variants associated with lumbar disc degeneration in northern Europeans:a meta-analysis of 4600 subjects.
Annals of the Rheumatic Diseases, 72 (7).
pp. 1141-8.
ISSN 0003-4967
Abstract
Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.
Item Type: | Article |
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Uncontrolled Keywords: | adult,aged,cpg islands,dna methylation,european continental ancestry group,female,genetic predisposition to disease,genome-wide association study,humans,intervertebral disc degeneration,lumbar vertebrae,male,middle aged,polymorphism, single nucleotide,ubiquitin-protein ligases |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Depositing User: | Pure Connector |
Date Deposited: | 27 Jan 2014 13:54 |
Last Modified: | 19 Apr 2023 00:01 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/47220 |
DOI: | 10.1136/annrheumdis-2012-201551 |
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