Williams, Frances M K, Bansal, Aruna T, van Meurs, Joyce B, Bell, Jordana T, Meulenbelt, Ingrid, Suri, Pradeep, Rivadeneira, Fernando, Sambrook, Philip N, Hofman, Albert, Bierma-Zeinstra, Sita, Menni, Cristina, Kloppenburg, Margreet, Slagboom, P Eline, Hunter, David J, MacGregor, Alex J, Uitterlinden, Andre G, Spector, Tim D and Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325
(2013)
Novel genetic variants associated with lumbar disc degeneration in northern Europeans:a meta-analysis of 4600 subjects.
Annals of the Rheumatic Diseases, 72 (7).
pp. 1141-8.
ISSN 0003-4967
Abstract
Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.
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