The third hydrogenase: A ferracyclic carbamoyl with close structural analogy to the active site of Hmd

Turrell, Peter J., Wright, Joseph A. ORCID: https://orcid.org/0000-0001-9603-1001, Peck, Jamie N. T., Oganesyan, Vasily S. ORCID: https://orcid.org/0000-0002-8738-1146 and Pickett, Christopher J. (2010) The third hydrogenase: A ferracyclic carbamoyl with close structural analogy to the active site of Hmd. Angewandte Chemie-International Edition, 49 (41). pp. 7508-7511. ISSN 1433-7851

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Abstract

The synthesis of a close structural analogue of the active site of [Fe]-hydrogenase is described (see structure; C gray, H dark blue, Fe green, N light blue, O red, S yellow). Nature most probably constructs the five membered ferracyclic ring to poise the 2-hydroxy pyridine substituent in a position to assist the heterolytic cleavage of dihydrogen, and the accessibility of the analogue should now provide opportunities for probing this.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Chemistry of Light and Energy Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Energy Materials Laboratory Faculty of Science > Research Groups > Centre for Photonics and Quantum Science
Depositing User:	Pure Connector
Date Deposited:	18 Dec 2013 12:40
Last Modified:	25 Sep 2024 11:05
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47070
DOI:	10.1002/anie.v49:41

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