The third hydrogenase: A ferracyclic carbamoyl with close structural analogy to the active site of Hmd

Turrell, Peter J., Wright, Joseph A., Peck, Jamie N. T., Oganesyan, Vasily S. and Pickett, Christopher J. (2010) The third hydrogenase: A ferracyclic carbamoyl with close structural analogy to the active site of Hmd. Angewandte Chemie-International Edition, 49 (41). pp. 7508-7511. ISSN 1433-7851

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Abstract

The synthesis of a close structural analogue of the active site of [Fe]-hydrogenase is described (see structure; C gray, H dark blue, Fe green, N light blue, O red, S yellow). Nature most probably constructs the five membered ferracyclic ring to poise the 2-hydroxy pyridine substituent in a position to assist the heterolytic cleavage of dihydrogen, and the accessibility of the analogue should now provide opportunities for probing this.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis (former - to 2025) Faculty of Science > Research Groups > Chemistry of Light and Energy (former - to 2025) Faculty of Science > Research Groups > Chemistry of Life Processes (former - to 2025) Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Energy Materials Laboratory (former - to 2025) Faculty of Science > Research Groups > Centre for Photonics and Quantum Science (former - to 2025) Faculty of Science > Research Groups > Synthetic and Medicinal Chemistry
Depositing User:	Pure Connector
Date Deposited:	18 Dec 2013 12:40
Last Modified:	04 Feb 2026 17:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47070
DOI:	10.1002/anie.v49:41

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