Programmable polymer-DNA hydrogels with dual input and multiscale responses

Sicilia, Giovanna, Grainger-Boultby, Christine, Francini, Nora, Magnusson, Johannes P., Saeed, Aram O. ORCID: https://orcid.org/0000-0003-2903-5875, Fernández-trillo, Francisco, Spain, Sebastian G. and Alexander, Cameron (2014) Programmable polymer-DNA hydrogels with dual input and multiscale responses. Biomaterials Science, 2. pp. 203-211. ISSN 2047-4830

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Abstract

Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.

Item Type:	Article
Additional Information:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	16 Dec 2013 16:52
Last Modified:	05 Mar 2024 17:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46957
DOI:	10.1039/c3bm60126a

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