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Johnson, Alan P., Warner, Marina, Carter, Michael and Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703
(2002)
In vitro activity of cephalosporin RWJ-54428 (MC-02479) against multidrug-resistant gram-positive cocci.
Antimicrobial Agents and Chemotherapy, 46 (2).
pp. 321-326.
ISSN 0066-4804
Abstract
RWJ-54428 (MC-02479) is a novel cephalosporin that binds to penicillin-binding protein (PBP) PBP 2' (PBP 2a) of methicillin-resistant staphylococci. Its in vitro activity was assessed against 472 gram-positive cocci, largely selected as epidemiologically unrelated isolates with multidrug resistance. The MIC at which 50% of isolates are inhibited (MIC(50)) and MIC(90) of RWJ-54428 for methicillin-resistant Staphylococcus aureus (MRSA) were 1 and 2 microg/ml, respectively, whereas they were 0.5 and 0.5 microg/ml, respectively, for methicillin-susceptible S. aureus. The MIC(50) and MIC(90) were 1 and 4 microg/ml, respectively, for methicillin-resistant coagulase-negative staphylococci (MRCoNS), whereas they were 0.25 and 1 microg/ml, respectively, for methicillin-susceptible isolates. The highest MICs for MRSA and MRCoNS isolates were 2 and 4 microg/ml, respectively. The MIC(50) and MIC(90) of RWJ-54428 for Enterococcus faecalis were 0.5 and 1 microg/ml, respectively, but they were 4 and 8 microg/ml, respectively, for Enterococcus faecium. For penicillin-susceptible, -intermediate, and -resistant pneumococci, the MIC(90)s of RWJ-54428 were 0.03, 0.25, and 0.5 microg/ml, respectively, with the highest MIC for a pneumococcus being 1 microg/ml, recorded for a strain for which penicillin and cefotaxime MICs were 8 and 4 microg/ml. MICs for Lancefield group A, B, C, and G streptococci were
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cephalosporins,drug resistance, bacterial,drug resistance, multiple,enterococcus faecalis,humans,microbial sensitivity tests,staphylococcus aureus,streptococcus,streptococcus pneumoniae |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jan 2014 12:40 |
| Last Modified: | 07 Aug 2023 16:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46761 |
| DOI: | 10.1128/AAC.46.2.321-326.2002 |
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