Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives

Wyatt, Paul G., Allen, Michael J., Chilcott, Josie, Foster, Alison, Livermore, David G. ORCID: https://orcid.org/0000-0002-9856-3703, Mordaunt, Jackie E., Scicinski, Jan and Woollard, Patrick M. (2002) Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 12 (10). pp. 1399-404. ISSN 0960-894X

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Abstract

Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.

Item Type:	Article
Uncontrolled Keywords:	animals,benzofurans,biological availability,dogs,drug design,humans,indoles,kinetics,models, molecular,molecular conformation,oxytocin,receptors, oxytocin,structure-activity relationship
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:40
Last Modified:	17 Jun 2024 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46759
DOI:	10.1016/S0960-894X(02)00159-2

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