Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives

Wyatt, Paul G., Allen, Michael J., Chilcott, Josie, Foster, Alison, Livermore, David G., Mordaunt, Jackie E., Scicinski, Jan and Woollard, Patrick M. (2002) Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 12 (10). pp. 1399-404. ISSN 0960-894X

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Abstract

Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.

Item Type:	Article
Uncontrolled Keywords:	animals,benzofurans,biological availability,dogs,drug design,humans,indoles,kinetics,models, molecular,molecular conformation,oxytocin,receptors, oxytocin,structure-activity relationship
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:40
Last Modified:	06 Feb 2025 04:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46759
DOI:	10.1016/S0960-894X(02)00159-2

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