Population structure and antibiotic resistance of Acinetobacter DNA group 2 and 13TU isolates from hospitals in the UK

Spence, Richard P., Towner, Kevin J., Henwood, Caroline J., James, Dorothy, Woodford, Neil and Livermore, David M. ORCID: https://orcid.org/0000-0002-9856-3703 (2002) Population structure and antibiotic resistance of Acinetobacter DNA group 2 and 13TU isolates from hospitals in the UK. Journal of Medical Microbiology, 51 (12). pp. 1107-1112. ISSN 0022-2615

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Abstract

A total of 287 Acinetobacter isolates belonging to DNA groups 2 (A. baumannii) and 13TU was collected consecutively from 46 hospitals and typed by randomly amplified polymorphic DNA fingerprinting with primers DAF-4 and ERIC-2. With a similarity coefficient of >/=72% as a cut-off value, 37 clusters of genotypically similar isolates (genotypes) were recognised. Four major clusters, found in 15, 12, 12 and 8 hospitals respectively, accounted for 42% of isolates, but only three of these predominant clusters were associated with outbreaks of infection in individual hospitals. Many of the isolates were resistant to multiple antibiotics, including expanded-spectrum beta-lactam agents, aminoglycosides, tetracyclines and fluoroquinolones, but >98% remained susceptible to carbapenems and colistin. Overall, the study demonstrated that a heterogeneous population of Acinetobacter DNA group 2 and 13TU isolates, frequently showing multiple resistance to antibiotics, was causing infections in UK hospitals, and that four predominant genotypes appeared to have disseminated among geographically distinct locations.

Item Type:	Article
Uncontrolled Keywords:	acinetobacter,acinetobacter infections,anti-bacterial agents,carbapenems,cluster analysis,colistin,dna fingerprinting,dna, bacterial,drug resistance, multiple, bacterial,female,genotype,great britain,humans,male,microbial sensitivity tests,molecular epidemiology,random amplified polymorphic dna technique
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:36
Last Modified:	10 Aug 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46753
DOI:	10.1099/0022-1317-51-12-1107

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