Population structure and antibiotic resistance of Acinetobacter DNA group 2 and 13TU isolates from hospitals in the UK

Spence, Richard P., Towner, Kevin J., Henwood, Caroline J., James, Dorothy, Woodford, Neil and Livermore, David M. (2002) Population structure and antibiotic resistance of Acinetobacter DNA group 2 and 13TU isolates from hospitals in the UK. Journal of Medical Microbiology, 51 (12). pp. 1107-1112. ISSN 0022-2615

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Abstract

A total of 287 Acinetobacter isolates belonging to DNA groups 2 (A. baumannii) and 13TU was collected consecutively from 46 hospitals and typed by randomly amplified polymorphic DNA fingerprinting with primers DAF-4 and ERIC-2. With a similarity coefficient of >/=72% as a cut-off value, 37 clusters of genotypically similar isolates (genotypes) were recognised. Four major clusters, found in 15, 12, 12 and 8 hospitals respectively, accounted for 42% of isolates, but only three of these predominant clusters were associated with outbreaks of infection in individual hospitals. Many of the isolates were resistant to multiple antibiotics, including expanded-spectrum beta-lactam agents, aminoglycosides, tetracyclines and fluoroquinolones, but >98% remained susceptible to carbapenems and colistin. Overall, the study demonstrated that a heterogeneous population of Acinetobacter DNA group 2 and 13TU isolates, frequently showing multiple resistance to antibiotics, was causing infections in UK hospitals, and that four predominant genotypes appeared to have disseminated among geographically distinct locations.

Item Type:	Article
Uncontrolled Keywords:	acinetobacter,acinetobacter infections,anti-bacterial agents,carbapenems,cluster analysis,colistin,dna fingerprinting,dna, bacterial,drug resistance, multiple, bacterial,female,genotype,great britain,humans,male,microbial sensitivity tests,molecular epidemiology,random amplified polymorphic dna technique
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:36
Last Modified:	06 Feb 2025 04:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46753
DOI:	10.1099/0022-1317-51-12-1107

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