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Stockdale, Mark W., Tysall, Luke, Johnson, Alan P., Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703 and Woodford, Neil
(2004)
Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563.
International Journal of Antimicrobial Agents, 23 (1).
pp. 88-91.
ISSN 0924-8579
Abstract
Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | enterococcus,microbial sensitivity tests,molecular sequence data,mutation,oxazolidinones,staphylococcal infections,staphylococcus |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jan 2014 12:34 |
| Last Modified: | 15 Aug 2023 13:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46744 |
| DOI: | 10.1016/j.ijantimicag.2003.06.004 |
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