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ToolsStockdale, Mark W., Tysall, Luke, Johnson, Alan P., Livermore, David M. and Woodford, Neil (2004) Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563. International Journal of Antimicrobial Agents, 23 (1). pp. 88-91. ISSN 0924-8579
Full text not available from this repository. (Request a copy)Abstract
Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | enterococcus,microbial sensitivity tests,molecular sequence data,mutation,oxazolidinones,staphylococcal infections,staphylococcus |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jan 2014 12:34 |
| Last Modified: | 28 Mar 2025 05:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46744 |
| DOI: | 10.1016/j.ijantimicag.2003.06.004 |
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