Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

Stockdale, Mark W., Tysall, Luke, Johnson, Alan P., Livermore, David M. ORCID: https://orcid.org/0000-0002-9856-3703 and Woodford, Neil (2004) Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563. International Journal of Antimicrobial Agents, 23 (1). pp. 88-91. ISSN 0924-8579

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Abstract

Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.

Item Type:	Article
Uncontrolled Keywords:	enterococcus,microbial sensitivity tests,molecular sequence data,mutation,oxazolidinones,staphylococcal infections,staphylococcus
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:34
Last Modified:	15 Aug 2023 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46744
DOI:	10.1016/j.ijantimicag.2003.06.004

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