Mutators among CTX-M beta-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance

Ellington, Matthew J, Livermore, David M, Pitt, Tyrone L, Hall, Lucinda M C and Woodford, Neil (2006) Mutators among CTX-M beta-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance. Journal of Antimicrobial Chemotherapy, 58 (4). pp. 848-52. ISSN 0305-7453

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Abstract

Fosfomycin is a possible oral treatment for lower urinary tract infections caused by Escherichia coli with CTX-M extended-spectrum beta-lactamases but is vulnerable to mutational resistance. Hypermutability among natural E. coli populations might facilitate the emergence of resistance to fosfomycin. We therefore examined the prevalence of mutators amongst urinary isolates of E. coli producing CTX-M beta-lactamases.

Item Type: Article
Uncontrolled Keywords: anti-bacterial agents,drug resistance, bacterial,escherichia coli,escherichia coli infections,fosfomycin,humans,microbial sensitivity tests,mutation,urinary tract infections,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:32
Last Modified: 21 Apr 2020 22:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/46719
DOI: 10.1093/jac/dkl315

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