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Ellington, Matthew J, Livermore, David M 
ORCID: https://orcid.org/0000-0002-9856-3703, Pitt, Tyrone L, Hall, Lucinda M C and Woodford, Neil
(2006)
Mutators among CTX-M beta-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance.
Journal of Antimicrobial Chemotherapy, 58 (4).
pp. 848-52.
ISSN 0305-7453
Abstract
Fosfomycin is a possible oral treatment for lower urinary tract infections caused by Escherichia coli with CTX-M extended-spectrum beta-lactamases but is vulnerable to mutational resistance. Hypermutability among natural E. coli populations might facilitate the emergence of resistance to fosfomycin. We therefore examined the prevalence of mutators amongst urinary isolates of E. coli producing CTX-M beta-lactamases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anti-bacterial agents,drug resistance, bacterial,escherichia coli,escherichia coli infections,fosfomycin,humans,microbial sensitivity tests,mutation,urinary tract infections,beta-lactamases |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jan 2014 12:32 |
| Last Modified: | 24 Oct 2022 05:46 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46719 |
| DOI: | 10.1093/jac/dkl315 |
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