In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci

Livermore, David M, Warner, Marina, Mushtaq, Shazad, North, Sarah and Woodford, Neil (2007) In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. Antimicrobial Agents and Chemotherapy, 51 (3). pp. 1112-4. ISSN 0066-4804

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Abstract

RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.

Item Type: Article
Uncontrolled Keywords: acetamides,anti-bacterial agents,drug resistance, bacterial,enterococcus faecalis,enterococcus faecium,methicillin resistance,microbial sensitivity tests,mutation,oxazolidinones,polymorphism, restriction fragment length,reverse transcriptase polymerase chain reaction,staphylococcus aureus
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:30
Last Modified: 21 Apr 2020 22:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/46713
DOI: 10.1128/AAC.01347-06

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