In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci

Livermore, David M ORCID: https://orcid.org/0000-0002-9856-3703, Warner, Marina, Mushtaq, Shazad, North, Sarah and Woodford, Neil (2007) In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. Antimicrobial Agents and Chemotherapy, 51 (3). pp. 1112-4. ISSN 0066-4804

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Abstract

RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.

Item Type:	Article
Uncontrolled Keywords:	acetamides,anti-bacterial agents,drug resistance, bacterial,enterococcus faecalis,enterococcus faecium,methicillin resistance,microbial sensitivity tests,mutation,oxazolidinones,polymorphism, restriction fragment length,reverse transcriptase polymerase chain reaction,staphylococcus aureus
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:30
Last Modified:	24 Oct 2022 05:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46713
DOI:	10.1128/AAC.01347-06

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