Mutation frequency in antibiotic-resistant and -susceptible isolates of Streptococcus pneumoniae

Henderson-Begg, Stephanie K, Sheppard, Carmen L, George, Robert C, Livermore, David M ORCID: and Hall, Lucinda M C (2010) Mutation frequency in antibiotic-resistant and -susceptible isolates of Streptococcus pneumoniae. International Journal of Antimicrobial Agents, 35 (4). pp. 342-6. ISSN 1872-7913

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Development of multiple antibiotic resistance in Streptococcus pneumoniae typically involves either mutation or transformation at several well-separated chromosomal loci. We postulated that this series of genetic events would be more likely to occur in organisms with deficient DNA repair mechanisms. Investigation of 27 antibiotic-resistant or -susceptible clinical isolates of S. pneumoniae revealed a broad range of mutation frequencies, but no isolate was as mutable as a mismatch repair (MMR)-deficient laboratory isolate. No correlation was observed between antibiotic resistance and higher mutation frequency. Examination of a further 180 clinical isolates using a newly developed rapid screen method also failed to identify any isolates with a mutation frequency as high as the MMR-deficient control strain. We argue that there is currently no clear evidence of a distinct population of mutators among clinical pneumococci.

Item Type: Article
Additional Information: (c) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Uncontrolled Keywords: anti-bacterial agents,drug resistance, bacterial,humans,microbial sensitivity tests,mutation,pneumococcal infections,streptococcus pneumoniae
Faculty \ School:
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:28
Last Modified: 24 Oct 2022 05:45
DOI: 10.1016/j.ijantimicag.2009.12.015

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