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Henderson-Begg, Stephanie K, Sheppard, Carmen L, George, Robert C, Livermore, David M 
ORCID: https://orcid.org/0000-0002-9856-3703 and Hall, Lucinda M C
(2010)
Mutation frequency in antibiotic-resistant and -susceptible isolates of Streptococcus pneumoniae.
International Journal of Antimicrobial Agents, 35 (4).
pp. 342-6.
ISSN 1872-7913
Abstract
Development of multiple antibiotic resistance in Streptococcus pneumoniae typically involves either mutation or transformation at several well-separated chromosomal loci. We postulated that this series of genetic events would be more likely to occur in organisms with deficient DNA repair mechanisms. Investigation of 27 antibiotic-resistant or -susceptible clinical isolates of S. pneumoniae revealed a broad range of mutation frequencies, but no isolate was as mutable as a mismatch repair (MMR)-deficient laboratory isolate. No correlation was observed between antibiotic resistance and higher mutation frequency. Examination of a further 180 clinical isolates using a newly developed rapid screen method also failed to identify any isolates with a mutation frequency as high as the MMR-deficient control strain. We argue that there is currently no clear evidence of a distinct population of mutators among clinical pneumococci.
| Item Type: | Article |
|---|---|
| Additional Information: | (c) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. |
| Uncontrolled Keywords: | anti-bacterial agents,drug resistance, bacterial,humans,microbial sensitivity tests,mutation,pneumococcal infections,streptococcus pneumoniae |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jan 2014 12:28 |
| Last Modified: | 24 Oct 2022 05:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46684 |
| DOI: | 10.1016/j.ijantimicag.2009.12.015 |
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