Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae

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Livermore, David M ORCID: https://orcid.org/0000-0002-9856-3703, Mushtaq, Shazad and Ge, Yigong (2010) Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae. Journal of Antimicrobial Chemotherapy, 65 (9). pp. 1972-4. ISSN 0305-7453

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Abstract

The developmental oxyimino-cephalosporin CXA-101 (FR264205) is notable for having greater antipseudomonal activity than ceftazidime. It is active against Enterobacteriaceae too, but is compromised by extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. We investigated the tazobactam concentrations needed to potentiate this cephalosporin against strains with these mechanisms.

Item Type:	Article
Uncontrolled Keywords:	anti-bacterial agents,bacterial proteins,cephalosporins,enterobacteriaceae,enzyme inhibitors,microbial sensitivity tests,penicillanic acid,beta-lactamases
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:54
Last Modified:	24 Oct 2022 05:45
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46677
DOI:	10.1093/jac/dkq248

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