Adverse drug reactions

Loke, Yoon K (2012) Adverse drug reactions. British Journal of Clinical Pharmacology, 73 (6). pp. 908-11. ISSN 0306-5251

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Abstract

Our ability to understand fully the characteristics of clinically important adverse drug reactions is hindered by a lack of emphasis on biological mechanisms, patient susceptibility factors and long-term outcomes. Assessment of drug safety needs to move beyond industry and regulatory perspectives, towards a greater focus on evidence-based preventive and management strategies that will allow patients and physicians to deal with adverse drug reactions at the bedside. This would ideally involve close collaboration between clinical pharmacologists and pharmacoepidemiologists skilled at interrogating the increasingly sophisticated electronic healthcare databases. In light of the myriad safety scares that are constantly emerging, patients and physicians would be best served by a centrally funded independent network of rapid-response drug safety researchers who can use techniques of teleoanalysis to describe fully the magnitude of risk, the potential biological mechanisms and patients' susceptibility factors.

Item Type:	Article
Additional Information:	© 2012 The Author. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
Uncontrolled Keywords:	adverse drug reaction reporting systems,clinical trials as topic,data interpretation, statistical,drug toxicity,great britain,humans,meta-analysis as topic,models, biological,pharmaceutical preparations,pharmacoepidemiology,pharmacology, clinical,research design
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 15:16
Last Modified:	19 Oct 2023 01:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46603
DOI:	10.1111/j.1365-2125.2012.04235.x

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