Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics:meta-analysis

Kwok, Chun Shing, Arthur, Aaron Kobina, Anibueze, Chukwudubem Ifeanyichukwu, Singh, Sonal, Cavallazzi, Rodrigo and Loke, Yoon Kong (2012) Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics:meta-analysis. The American Journal of Gastroenterology, 107 (7). pp. 1011-9. ISSN 0002-9270

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Abstract

Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).

Item Type:	Article
Uncontrolled Keywords:	anti-bacterial agents,clostridium difficile,enterocolitis, pseudomembranous,histamine h2 antagonists,humans,incidence,proton pump inhibitors,recurrence,risk factors
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health (former - to 2025) Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) Faculty of Medicine and Health Sciences > Research Centres > Public Health
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:48
Last Modified:	30 Jul 2025 09:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46600
DOI:	10.1038/ajg.2012.108

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