Delayed acetyl-L-carnitine administration and its effect on sensory neuronal rescue after peripheral nerve injury

Wilson, Andrew D H, Hart, Andrew, Brännström, Thomas, Wiberg, Mikael and Terenghi, Giorgio (2007) Delayed acetyl-L-carnitine administration and its effect on sensory neuronal rescue after peripheral nerve injury. Journal of Plastic, Reconstructive & Aesthetic Surgery, 60 (2). pp. 114-8. ISSN 1748-6815

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Abstract

Protection of sensory neurons after peripheral nerve injury is clinically crucial since inadequate sensory recovery is seriously affected by the death of up to 40% of sensory neurons. Immediate acetyl-L-carnitine (ALCAR) treatment eliminates this cell loss, but may not always be clinically feasible, hence we studied the effect of delaying the initiation of ALCAR treatment. Five groups of rats (n=5 per group) underwent unilateral sciatic nerve axotomy. ALCAR treatment (50 mg/kg/day) was initiated immediately, or after delays of 6 h, 24 h or 7 days after injury. A sham-treated group served as control. L4 and L5 dorsal root ganglia were harvested bilaterally 2 weeks after injury and stereological sensory neuron counts were obtained. Immediate sham treatment provided no neuroprotection (25% loss). Cell loss was eliminated when ALCAR was commenced within

Item Type:	Article
Uncontrolled Keywords:	acetylcarnitine,animals,axotomy,cell count,ganglia, spinal,injections, intraperitoneal,lumbar vertebrae,neurons, afferent,neuroprotective agents,rats,rats, sprague-dawley,sciatic nerve,time factors
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Respiratory and Airways Group Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:42
Last Modified:	13 Nov 2023 16:57
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46523
DOI:	10.1016/j.bjps.2006.04.017

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