Acetyl-l-carnitine increases nerve regeneration and target organ reinnervation - a morphological study

Wilson, Andrew D H, Hart, Andrew, Wiberg, Mikael and Terenghi, Giorgio (2010) Acetyl-l-carnitine increases nerve regeneration and target organ reinnervation - a morphological study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63 (7). pp. 1186-95. ISSN 1878-0539

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Abstract

Peripheral nerve injury frequently results in functional morbidity since standard management fails to adequately address many of the neurobiological hurdles to optimal regeneration. Neuronal survival and regeneration are neurotrophin dependent and require increased aerobic capacity. Acetyl-l-carnitine (ALCAR) facilitates this need and prevents neuronal loss. ALCAR is clinically safe and is shown here to significantly improve nerve regeneration and target organ reinnervation. Two groups of five rats underwent sciatic nerve division followed by immediate repair. One group received parenteral ALCAR (50mg/kg/day) from time of operation until termination at 12 weeks. A 'sham treatment' group received normal saline. A third group was left unoperated and did not receive any treatment. A segment of nerve was harvested between 5mm proximal and 10mm distal to the repair in operated groups, and at the corresponding level in the unoperated group. Mean axonal count in normal, non-axotomised nerve was 14,720 (SD 2378). That of the saline group (17,217 SD 1808) was not significantly different from normal nerve (P=0.0985). Mean number of myelinated axons in the ALCAR group (24,460 SD 3750) was significantly greater than both sham group (P

Item Type:	Article
Additional Information:	Copyright 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Uncontrolled Keywords:	acetylcarnitine,animals,axons,hindlimb,muscle, skeletal,nerve fibers, myelinated,nerve regeneration,organ size,rats,rats, sprague-dawley,sciatic nerve,skin,vitamin b complex
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Respiratory and Airways Group Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 15:02
Last Modified:	13 Nov 2023 16:57
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46511
DOI:	10.1016/j.bjps.2009.05.039

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