Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats

Clark, Jeremy J, Nasrallah, Nicholas A, Hart, Andrew S, Collins, Anne L, Bernstein, Ilene L and Phillips, Paul E M (2012) Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats. PLoS One, 7 (5). ISSN 1932-6203

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Abstract

Alcohol use during adolescence has profound and enduring consequences on decision-making under risk. However, the fundamental psychological processes underlying these changes are unknown. Here, we show that alcohol use produces over-fast learning for better-than-expected, but not worse-than-expected, outcomes without altering subjective reward valuation. We constructed a simple reinforcement learning model to simulate altered decision making using behavioral parameters extracted from rats with a history of adolescent alcohol use. Remarkably, the learning imbalance alone was sufficient to simulate the divergence in choice behavior observed between these groups of animals. These findings identify a selective alteration in reinforcement learning following adolescent alcohol use that can account for a robust change in risk-based decision making persisting into later life.

Item Type: Article
Uncontrolled Keywords: alcohol drinking,animals,choice behavior,computer simulation,conditioning, operant,decision making,learning,male,models, psychological,rats,rats, sprague-dawley,reinforcement (psychology),risk
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 14:12
Last Modified: 21 Apr 2020 22:35
URI: https://ueaeprints.uea.ac.uk/id/eprint/46489
DOI: 10.1371/journal.pone.0037357

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