Tools
ToolsClark, Jeremy J., Nasrallah, Nicholas A., Hart, Andrew S., Collins, Anne L., Bernstein, Ilene L. and Phillips, Paul E. M. (2012) Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats. PLoS One, 7 (5). ISSN 1932-6203
Full text not available from this repository.Abstract
Alcohol use during adolescence has profound and enduring consequences on decision-making under risk. However, the fundamental psychological processes underlying these changes are unknown. Here, we show that alcohol use produces over-fast learning for better-than-expected, but not worse-than-expected, outcomes without altering subjective reward valuation. We constructed a simple reinforcement learning model to simulate altered decision making using behavioral parameters extracted from rats with a history of adolescent alcohol use. Remarkably, the learning imbalance alone was sufficient to simulate the divergence in choice behavior observed between these groups of animals. These findings identify a selective alteration in reinforcement learning following adolescent alcohol use that can account for a robust change in risk-based decision making persisting into later life.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | alcohol drinking,animals,choice behavior,computer simulation,conditioning, operant,decision making,learning,male,models, psychological,rats,rats, sprague-dawley,reinforcement (psychology),risk,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 06 Jan 2014 14:12 |
| Last Modified: | 06 Jun 2024 14:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46489 |
| DOI: | 10.1371/journal.pone.0037357 |
Actions (login required)
 |
View Item |