Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats

Clark, Jeremy J., Nasrallah, Nicholas A., Hart, Andrew S., Collins, Anne L., Bernstein, Ilene L. and Phillips, Paul E. M. (2012) Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats. PLoS One, 7 (5). ISSN 1932-6203

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Abstract

Alcohol use during adolescence has profound and enduring consequences on decision-making under risk. However, the fundamental psychological processes underlying these changes are unknown. Here, we show that alcohol use produces over-fast learning for better-than-expected, but not worse-than-expected, outcomes without altering subjective reward valuation. We constructed a simple reinforcement learning model to simulate altered decision making using behavioral parameters extracted from rats with a history of adolescent alcohol use. Remarkably, the learning imbalance alone was sufficient to simulate the divergence in choice behavior observed between these groups of animals. These findings identify a selective alteration in reinforcement learning following adolescent alcohol use that can account for a robust change in risk-based decision making persisting into later life.

Item Type: Article
Uncontrolled Keywords: alcohol drinking,animals,choice behavior,computer simulation,conditioning, operant,decision making,learning,male,models, psychological,rats,rats, sprague-dawley,reinforcement (psychology),risk,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 14:12
Last Modified: 06 Jun 2024 14:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/46489
DOI: 10.1371/journal.pone.0037357

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