Effect of fasting versus feeding on the bone metabolic response to running

Scott, Jonathan P R, Sale, Craig, Greeves, Julie P, Casey, Anna, Dutton, John and Fraser, William D (2012) Effect of fasting versus feeding on the bone metabolic response to running. Bone, 51 (6). pp. 990-9. ISSN 8756-3282

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Abstract

Individuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-active males aged 28 ± 4y (mean ±SD) completed two, counterbalanced, 8d trials. After 3d on a standardised diet, participants performed 60 min of treadmill running at 65% VO(2max) on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before and during exercise, for 3h after exercise, and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for the c-terminal telopeptide region of collagen type 1 (β-CTX), n-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone alkaline phosphatase (bone ALP), parathyroid hormone (PTH), albumin-adjusted calcium, phosphate, osteoprotegerin (OPG), cortisol, leptin and ghrelin. Only the β-CTX response was significantly affected by feeding. Pre-exercise concentrations decreased more in FED compared with FAST (47% vs 26%, P

Item Type:	Article
Additional Information:	Copyright © 2012 Elsevier Inc. All rights reserved.
Uncontrolled Keywords:	adult,bone resorption,bone and bones,fasting,ghrelin,humans,leptin,male,osteocalcin,parathyroid hormone,procollagen,running
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:22
Last Modified:	14 Oct 2025 23:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46374
DOI:	10.1016/j.bone.2012.08.128

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