Generalizing results of randomized trials to clinical practice:reliability and cautions

Flather, Marcus, Delahunty, Nicola and Collinson, Julian (2006) Generalizing results of randomized trials to clinical practice:reliability and cautions. Clinical Trials, 3 (6). pp. 508-12. ISSN 1740-7745

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Abstract

Well designed randomized controlled trials provide reliable evidence of treatment effects, but there is no consensus on how best to apply these results to clinical practice. The main concerns are that populations enrolled in trials are more selected than those treated in a clinical setting, and whether the treatment effects observed in trials will also be observed in clinical practice.

Item Type:	Article
Uncontrolled Keywords:	humans,patient compliance,patient selection,randomized controlled trials as topic,reproducibility of results,research design
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:14
Last Modified:	24 Oct 2022 05:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46275
DOI:	10.1177/1740774506073464

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