Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction:the GEOSTAT-1 Study

Bailey, Kristian M, Romaine, Simon P R, Jackson, Beryl M, Farrin, Amanda J, Efthymiou, Maria, Barth, Julian H, Copeland, Joanne, McCormack, Terry, Whitehead, Andrew, Flather, Marcus D, Samani, Nilesh J, Nixon, Jane, Hall, Alistair S and Balmforth, Anthony J and SPACE ROCKET Trial Group (2010) Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction:the GEOSTAT-1 Study. Circulation: Cardiovascular Genetics, 3 (3). pp. 276-85. ISSN 1942-3268

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Abstract

Pharmacogenetics aims to maximize benefits and minimize risks of drug treatment. Our objectives were to examine the influence of common variants of hepatic metabolism and transporter genes on the lipid-lowering response to statin therapy.

Item Type:	Article
Uncontrolled Keywords:	atp-binding cassette transporters,aged,cholesterol, ldl,cytochrome p-450 cyp3a,cytochrome p-450 enzyme system,female,fluorobenzenes,genotype,humans,hydroxymethylglutaryl-coa reductase inhibitors,male,middle aged,myocardial infarction,neoplasm proteins,odds ratio,organic anion transporters,polymorphism, single nucleotide,pyrimidines,regression analysis,simvastatin,sulfonamides
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:12
Last Modified:	03 Nov 2022 15:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46252
DOI:	10.1161/CIRCGENETICS.109.898502

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