Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease

Goto, Shinya, Ogawa, Hisao, Takeuchi, Masaru, Flather, Marcus D and Bhatt, Deepak L and J-LANCELOT (Japanese-Lesson from Antagonizing the Cellular Effect of Thrombin) Investigators (2010) Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease. European Heart Journal, 31 (21). pp. 2601-13. ISSN 0195-668X

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Abstract

Two multicentre, randomized, double-blind, placebo-controlled Phase II studies assessed the safety and efficacy of the oral protease-activated receptor 1 (PAR-1) antagonist E5555 in addition to standard therapy in Japanese patients with acute coronary syndrome (ACS) or high-risk coronary artery disease (CAD).

Item Type:	Article
Uncontrolled Keywords:	acute coronary syndrome,administration, oral,coronary artery disease,double-blind method,drug-induced liver injury,female,hemorrhage,humans,imines,long qt syndrome,male,middle aged,platelet aggregation inhibitors,pyridines,receptor, par-1
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:12
Last Modified:	03 Nov 2022 15:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46246
DOI:	10.1093/eurheartj/ehq320

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