Randomized trial of atopaxar in the treatment of patients with coronary artery disease:the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial

Wiviott, Stephen D, Flather, Marcus D, O'Donoghue, Michelle L, Goto, Shinya, Fitzgerald, Desmond J, Cura, Fernando, Aylward, Philip, Guetta, Victor, Dudek, Dariusz, Contant, Charles F, Angiolillo, Dominick J and Bhatt, Deepak L and LANCELOT-CAD Investigators (2011) Randomized trial of atopaxar in the treatment of patients with coronary artery disease:the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial. Circulation, 123 (17). pp. 1854-63. ISSN 0009-7322

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Abstract

Thrombin is a key mediator of platelet activation. Atopaxar is a reversible protease-activated receptor-1 antagonist that interferes with thrombin-mediated platelet effects. The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LANCELOT-CAD) trial examined the safety and tolerability of prolonged therapy with atopaxar in subjects with CAD.

Item Type:	Article
Uncontrolled Keywords:	aged,biological markers,blood platelets,coronary artery disease,dose-response relationship, drug,female,hemorrhage,humans,imines,male,middle aged,platelet activation,platelet aggregation inhibitors,pyridines,receptors, thrombin
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:12
Last Modified:	03 Nov 2022 15:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46238
DOI:	10.1161/CIRCULATIONAHA.110.001404

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