The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients:the CHARISMA genetics study

Bhatt, Deepak L, Paré, Guillaume, Eikelboom, John W, Simonsen, Katy L, Emison, Eileen S, Fox, Keith A A, Steg, Ph Gabriel, Montalescot, Gilles, Bhakta, Nihar, Hacke, Werner, Flather, Marcus D, Mak, Koon-Hou, Cacoub, Patrice, Creager, Mark A, Berger, Peter B, Steinhubl, Steven R, Murugesan, Gurunathan, Mehta, Shamir R, Kottke-Marchant, Kandice, Lincoff, A Michael and Topol, Eric J and CHARISMA Investigators (2012) The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients:the CHARISMA genetics study. European Heart Journal, 33 (17). pp. 2143-50. ISSN 0195-668X

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Abstract

Clinical trials have established the value of clopidogrel therapy in a wide spectrum of patients with cardiovascular diseases. Both loss- and gain-of-function single nucleotide variants of CYP2C19 genes have been identified that affect clopidogrel metabolism and anti-platelet response. We sought to determine the impact of CYP2C19 polymorphisms on ischaemic and bleeding events.

Item Type:	Article
Uncontrolled Keywords:	aryl hydrocarbon hydroxylases,atherosclerosis,female,genotype,hemorrhage,heterozygote,humans,ischemia,kaplan-meier estimate,male,middle aged,myocardial infarction,platelet aggregation inhibitors,polymorphism, genetic,stroke,thrombosis,ticlopidine,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:12
Last Modified:	03 Nov 2022 15:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46230
DOI:	10.1093/eurheartj/ehs059

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