Changes in the organization of excitation-contraction coupling structures in failing human heart

Crossman, David J., Ruygrok, Peter R., Soeller, Christian and Cannell, Mark B. (2011) Changes in the organization of excitation-contraction coupling structures in failing human heart. PLoS One, 6 (3). ISSN 1932-6203

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Abstract

The cardiac myocyte t-tubular system ensures rapid, uniform cell activation and several experimental lines of evidence suggest changes in the t-tubular system and associated excitation-contraction coupling proteins may occur in heart failure.

Item Type:	Article
Additional Information:	© 2011 Crossman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords:	actin cytoskeleton,aged,calcium channels, l-type,excitation contraction coupling,heart failure,humans,magnetic resonance imaging,middle aged,myocytes, cardiac,ryanodine receptor calcium release channel,sarcolemma,sarcoplasmic reticulum,staining and labeling,wheat germ agglutinins
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 15:40
Last Modified:	14 Oct 2025 23:41
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46191
DOI:	10.1371/journal.pone.0017901

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