Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma:a report from the Children's Oncology Group

Pressey, Joseph G, Anderson, James R, Crossman, David K, Lynch, James C and Barr, Frederic G (2011) Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma:a report from the Children's Oncology Group. Pediatric Blood & Cancer, 57 (6). pp. 930-8. ISSN 1545-5017

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Abstract

Aberrant activation of the hedgehog (Hh) signaling pathway is implicated widely in both pediatric and adult malignancies. Inactivation of the Hh regulator PTCH is responsible for the Gorlin cancer predisposition syndrome. The spectrum of tumors found in Gorlin Syndrome includes basal cell carcinoma, medulloblastoma, and rarely, rhabdomyosarcoma (RMS). A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors.

Item Type:	Article
Additional Information:	Copyright © 2011 Wiley-Liss, Inc.
Uncontrolled Keywords:	cell line, tumor,hedgehog proteins,humans,oligonucleotide array sequence analysis,rna, messenger,receptors, cell surface,rhabdomyosarcoma,sarcoma,signal transduction,transcription factors,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:04
Last Modified:	24 Oct 2022 05:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46190
DOI:	10.1002/pbc.23174

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