Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F

White, C Roger, Smythies, Lesley E, Crossman, David K, Palgunachari, Mayakonda N, Anantharamaiah, G M and Datta, Geeta (2012) Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F. Arteriosclerosis, Thrombosis, and Vascular Biology, 32 (11). pp. 2631-9. ISSN 1079-5642

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Abstract

The apolipoprotein A-I (apoA-I) mimetic peptide 4F favors the differentiation of human monocytes to an anti-inflammatory phenotype and attenuates lipopolysaccharide (LPS)-induced inflammatory responses. We investigated the effects of LPS on the Toll-like receptor (TLR) signaling pathway in 4F-differentiated monocyte-derived macrophages.

Item Type:	Article
Uncontrolled Keywords:	active transport, cell nucleus,anti-inflammatory agents,apolipoprotein a-i,caveolin 1,cells, cultured,cholesterol,cytokines,down-regulation,flow cytometry,gene expression profiling,humans,inflammation,inflammation mediators,lipopolysaccharides,macrophages,membrane microdomains,oligonucleotide array sequence analysis,peptides,phosphorylation,reverse transcriptase polymerase chain reaction,signal transduction,time factors,toll-like receptors,transcription factor rela,transcription, genetic
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:02
Last Modified:	24 Oct 2022 05:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46179
DOI:	10.1161/ATVBAHA.112.300167

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