Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays

Clark, Jeremy, Edwards, Sandra, Feber, Andrew, Flohr, Penny, John, Megan, Giddings, Ian, Crossland, Sue, Stratton, Michael R, Wooster, Richard, Campbell, Colin and Cooper, Colin S ORCID: https://orcid.org/0000-0003-2013-8042 (2003) Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays. Oncogene, 22 (8). pp. 1247-52. ISSN 0950-9232

Full text not available from this repository. (Request a copy)

Abstract

We demonstrate that comparative genomic hybridization (CGH) onto cDNA microarrays may be used to carry out genome-wide screens for regions of genetic loss, including homozygous (complete) deletions that may represent the possible location of tumour suppressor genes in human cancer. Screening of the prostate cancer cell lines LNCaP, PC3 and DU145 allowed the mapping of specific regions where genome copy number appeared altered and led to the identification of two novel regions of complete loss at 17q21.31 (500 kb spanning STAT3) and at 10q23.1 (50-350 kb spanning SFTPA2) in the PC3 cell line.

Item Type:	Article
Uncontrolled Keywords:	adenocarcinoma,chromosome mapping,chromosomes, human, pair 10,chromosomes, human, pair 17,dna, complementary,dna, neoplasm,female,gene deletion,gene expression profiling,humans,male,nucleic acid hybridization,oligonucleotide array sequence analysis,prostatic neoplasms,tumor cells, cultured,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 14:14
Last Modified:	06 Jun 2024 14:43
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46167
DOI:	10.1038/sj.onc.1206247

Actions (login required)

View Item