Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones

McIntyre, Alan, Summersgill, Brenda, Jafer, Osman, Rodriguez, Sandrine, Zafarana, Gaetano, Oosterhuis, J Wolter, Gillis, Ad Jm, Looijenga, Leendert, Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Huddart, Robert, Clark, Jeremy and Shipley, Janet (2004) Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones. Oncogene, 23 (56). pp. 9142-7. ISSN 0950-9232

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Abstract

Identifying changes in DNA copy number can pinpoint genes that may be involved in tumor development. Here we have defined the smallest overlapping regions of imbalance (SORI) in testicular germ cell tumors other than the 12p region, which has been previously investigated. Definition of the regions was achieved through comparative genomic hybridization (CGH) analysis of a 4559 cDNA clone microarray. A total of 14 SORI were identified, which involved at least five of the 11 samples analysed. Many of these refined regions were previously reported using chromosomal or allelic imbalance studies. The SORI included gain of material from the regions 4q12, 17q21.3, 22q11.23 and Xq22, and loss from 5q33, 11q12.1, 16q22.3 and 22q11. Comparison with parallel chromosomal CGH data supported involvement of most regions. The various SORI span between one and 20 genes and highlight potential oncogenes/tumor suppressor genes to be investigated further.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,chromosome mapping,dna, complementary,germinoma,humans,male,oligonucleotide array sequence analysis,testicular neoplasms
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:02
Last Modified:	06 Jun 2024 14:43
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46162
DOI:	10.1038/sj.onc.1208115

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