Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer

Kudahetti, Sakunthala C, Fisher, Gabrielle, Ambroisine, Laurence, Prowse, David, Kattan, Michael W, Foster, Christopher S, Møller, Henrik, Oliver, Tim, Fletcher, Anne, Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Reuter, Victor, Scardino, Peter, Cuzick, Jack and Berney, Daniel M and Transatlantic Prostate Group (2010) Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer. Plant Pathology, 42 (6). pp. 519-23. ISSN 0032-0862

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Abstract

Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle markers, Rb, p21 and p16, would provide helpful prognostic information in a well characterised series of prostate cancers which were clinically localised and treated conservatively.

Item Type:	Article
Uncontrolled Keywords:	cyclin-dependent kinase inhibitor p16,cyclin-dependent kinase inhibitor p21,humans,immunohistochemistry,kaplan-meier estimate,male,neoplasm staging,prognosis,prostatic neoplasms,retinoblastoma protein,tissue array analysis,treatment outcome,tumor markers, biological,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 15:58
Last Modified:	03 Nov 2022 15:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46128
DOI:	10.3109/00313025.2010.508788

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