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Butler, Michael F, Clark, Allan H 
ORCID: https://orcid.org/0000-0003-2965-8941 and Adams, Sarah
(2006)
Swelling and mechanical properties of biopolymer hydrogels containing chitosan and bovine serum albumin.
Biomacromolecules, 7 (11).
pp. 2961-70.
ISSN 1525-7797
Abstract
Experimental and theoretical investigations of the swelling and mechanical properties of hydrogels formed from chitosan, bovine serum albumin (BSA), and chitosan/BSA mixtures cross-linked with genipin were performed. The properties of cross-linked chitosan hydrogels were explained in terms of its polyelectrolyte behavior, which led to a gradual increase in swelling ratio below the pK value, but whereby its swelling ability was eliminated by the presence of salt that screened the charges. Comparison of theoretical and experimental calculations of the swelling ratio, however, indicated that complications arising from wastage of cross-links, and formation of polymerized genipin cross-links must be considered before quantitative prediction can be achieved. Cross-linked BSA hydrogels swelled even in the presence of salt, and a marked increase in swelling was observed below pH = 3 that was explained as the result of an acid induced denaturation of the protein that led to unfolding of the molecule. Swollen BSA hydrogels were mechanically weak, however. Composite gels made from a cross-linked mixture of chitosan and BSA exhibited the swelling behavior of BSA combined with the mechanical properties of chitosan and were therefore considered most suitable for use in a gastric environment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | animals,biopolymers,cattle,chitosan,hydrogels,serum albumin, bovine |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 20 Jan 2014 15:56 |
| Last Modified: | 19 Oct 2023 01:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46107 |
| DOI: | 10.1021/bm060133y |
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