Targeted metabolomics profiles are strongly correlated with nutritional patterns in women

Menni, Cristina, Zhai, Guangju, Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325, Prehn, Cornelia, Römisch-Margl, Werner, Suhre, Karsten, Adamski, Jerzy, Cassidy, Aedin, Illig, Thomas, Spector, Tim D and Valdes, Ana M (2013) Targeted metabolomics profiles are strongly correlated with nutritional patterns in women. Metabolomics, 9 (2). pp. 506-514. ISSN 1573-3882

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Abstract

Nutrition plays an important role in human metabolism and health. Metabolomics is a promising tool for clinical, genetic and nutritional studies. A key question is to what extent metabolomic profiles reflect nutritional patterns in an epidemiological setting. We assessed the relationship between metabolomic profiles and nutritional intake in women from a large cross-sectional community study. Food frequency questionnaires (FFQs) were applied to 1,003 women from the TwinsUK cohort with targeted metabolomic analyses of serum samples using the Biocrates Absolute-IDQ™ Kit p150 (163 metabolites). We analyzed seven nutritional parameters: coffee intake, garlic intake and nutritional scores derived from the FFQs summarizing fruit and vegetable intake, alcohol intake, meat intake, hypo-caloric dieting and a "traditional English" diet. We studied the correlation between metabolite levels and dietary intake patterns in the larger population and identified for each trait between 14 and 20 independent monozygotic twins pairs discordant for nutritional intake and replicated results in this set. Results from both analyses were then meta-analyzed. For the metabolites associated with nutritional patterns, we calculated heritability using structural equation modelling. 42 metabolite nutrient intake associations were statistically significant in the discovery samples (Bonferroni P

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 15:42
Last Modified: 18 Apr 2023 23:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/46005
DOI: 10.1007/s11306-012-0469-6

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