Comparison of the effectiveness of a milk-free soy-maize-sorghum-based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children:an equivalence non-blinded cluster randomised controlled trial

Irena, Abel H, Bahwere, Paluku, Owino, Victor O, Diop, Elhadji I, Bachmann, Max O ORCID: https://orcid.org/0000-0003-1770-3506, Mbwili-Muleya, Clara, Dibari, Filippo, Sadler, Kate and Collins, Steve (2015) Comparison of the effectiveness of a milk-free soy-maize-sorghum-based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children:an equivalence non-blinded cluster randomised controlled trial. Maternal & Child Nutrition, 11 (Supplement S4). 105–119. ISSN 1740-8709

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Abstract

Community-based Management of Acute Malnutrition using ready-to-use therapeutic food (RUTF) has revolutionised the treatment of severe acute malnutrition (SAM). However, 25% milk content in standard peanut-based RUTF (P-RUTF) makes it too expensive. The effectiveness of milk-free RUTF has not been reported hitherto. This non-blinded, parallel group, cluster randomised, controlled, equivalence trial that compares the effectiveness of a milk-free soy-maize-sorghum-based RUTF (SMS-RUTF) with P-RUTF in treatment of children with SAM, closes the gap. A statistician randomly assigned health centres (HC) either to the SMS-RUTF (n = 12; 824 enrolled) or P-RUTF (n = 12; 1103 enrolled) arms. All SAM children admitted at the participating HCs were enrolled. All the outcomes were measured at individual level. Recovery rate was the primary outcome. The recovery rates for SMS-RUTF and P-RUTF were 53.3% and 60.8% for the intention-to-treat (ITT) analysis and 77.9% and 81.8% for per protocol (PP) analyses, respectively. The corresponding adjusted risk difference (ARD) and 95% confidence interval, were -7.6% (-14.9, 0.6%) and -3.5% (-9,6., 2.7%) for ITT (P = 0.034) and PP analyses (P = 0.257), respectively. An unanticipated interaction (interaction P

Item Type:	Article
Additional Information:	© 2013 John Wiley & Sons Ltd.
Uncontrolled Keywords:	severe acute malnutrition,rutf,zambia,recovery rate,sdg 2 - zero hunger ,/dk/atira/pure/sustainabledevelopmentgoals/zero_hunger
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	Pure Connector
Date Deposited:	16 Dec 2013 15:10
Last Modified:	19 Oct 2023 01:12
URI:	https://ueaeprints.uea.ac.uk/id/eprint/45940
DOI:	10.1111/mcn.12054

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