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Cate, H., Bhattacharya, D. 
ORCID: https://orcid.org/0000-0003-3024-7453, Clark, A., Holland, R. and Broadway, D. C.
(2013)
Patterns of adherence behaviour for patients with glaucoma.
Eye, 27 (4).
pp. 545-553.
ISSN 0950-222X
Abstract
Aims and purpose: Adherence to long-term treatment regimens for primary open-angle glaucoma holds a challenge for both clinicians and patients. The study aims were to (i) establish the magnitude of travoprost non-adherence using an Electronic Adherence Monitor (EAM), (ii) compare electronic with patient self-reported adherence, and (iii) explore the application of a previously reported method of graphically presenting adherence data to a larger cohort over a longer monitoring period. Methods: A cohort study of patients using travoprost for glaucoma or ocular hypertension was conducted. All participants used an EAM and adherence data were collected prospectively for 2 months. Self-reported adherence was obtained using the Morisky Medication Adherence Scale (MMAS); patients also reported frequency of missed doses. Potential predictors of adherence were collected via a structured interview. EAM-recorded interdose intervals were plotted graphically. Results: Of 100 patients invited to participate, 98 consented and EAM data were collected successfully from 88 participants. The median EAM adherence score for the cohort was 88.9% (interquartile range: 71.2, 92.2). When dichotomised (=80%: adherent; <80%: non-adherent), EAM identified 36.7% as non-adherent and MMAS 12.2%. EAM data were used to classify five types of adherence behaviour including a category representing levels of =97% maintained by 21% of participants. Conclusion: EAM revealed good adherence to glaucoma monotherapy but poor agreement with patient self-reported adherence. An adherence category of persistent and exceptionally high adherence to travoprost over a 2-month period was identified.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science Faculty of Social Sciences > School of Education and Lifelong Learning Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Patient Care |
| Depositing User: | Pure Connector |
| Date Deposited: | 04 Dec 2013 10:46 |
| Last Modified: | 24 Sep 2024 12:48 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/45441 |
| DOI: | 10.1038/eye.2012.294 |
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