Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

Simpson, J E, Ince, P G, Haynes, L J, Theaker, R, Gelsthorpe, C, Baxter, L, Forster, G, Lace, G L, Shaw, P J, Matthews, F E, Savva, G M, Brayne, C and Wharton, S B and MRC Cognitive Function and Ageing Neuropathology Study Group (2010) Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 36 (1). pp. 25-40. ISSN 1365-2990

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Abstract

Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken into account the effect of oxidative stress on astrocytes, and their contribution to pathology.

Item Type:	Article
Uncontrolled Keywords:	aged,aging,alzheimer disease,astrocytes,blotting, western,brain,dna damage,dna-activated protein kinase,deoxyguanosine,histones,humans,immunohistochemistry,neurons,oxidative stress
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health in Later Life (former - to 2017) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	Pure Connector
Date Deposited:	02 Dec 2013 14:30
Last Modified:	04 Dec 2023 01:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/44943
DOI:	10.1111/j.1365-2990.2009.01030.x

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